University of Minnesota
Medical School
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Meniere Diseease research                 

Posting expires on 08/31/2018

Research Site:
University of Minnesota - Duluth

Type of Research:
Basic Science

Department:
Other

This opportunity does not have a stipend.

Description:
Ménières disease (MD) is an episodic disease characterized by vertigo, hearing loss and tinnitus.  The prevailing hypothesis is that MD is caused by disruption of endolymph homeostasis, but there is still considerable controversy regarding the molecular mechanisms that result in the characteristic Ménières symptoms. This incomplete understanding of the disease process severely limits rational treatment design.  The global hypothesis of this research is that natriuretic peptides (NPs) represent a link between changes in plasma volume and the physiological changes that occur in the inner ear during an acute MD attack.   Loss- and gain-of-function models of natriuretic peptide function developed in our laboratory support the hypothesis that cGMP and NPs are important regulators of cochlear function. 

Experimental approaches used in our laboratory include the use of knockout mice to  study the effects of manipulations of the natriuretic peptide system.  Human studies are in the design stages.

For more information, please contact either Dr. Janet Fitzakerley (jfitzake@d.umn.edu) or Dr. George Trachte (gtracht1@d.umn.edu).

Posted on 12/31/2013