University of Minnesota
Medical School
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Brain Imaging Research                 

Posting expires on 01/05/2018

Research Site:
Minneapolis VA Health Care System

Type of Research:


This opportunity does not have a stipend.

Our laboratory (Cognitive Neuroimaging Unit) is interested in the biology of neuropsychiatric disease with a particular emphasis on brain imaging. Two projects are active at this time.
The first involves research on cognitive aging: What happens to the brain when otherwise healthy people age. We have found that the anterior cingulate cortex, a region involved in attention and other executive functions, declines markedly in metabolism with normal aging beginning in the early 40s. This metabolic decline correlates with age-associated cognitive decline and likely contributes to progression toward dementia in the elderly. Surprisingly, essentially nothing is known about what pathological process is occurring: Are synapses, neurons, or glia being lost? What biochemical changes are occurring? Can this decline be prevented or ameliorated?
The second line of inquiry focuses on mood and anxiety disorders. How do anti-anxiety and antidepressants work? Can biomarkers predict which treatments are likely to work? What is the system neuroscience of different depression phenotypes?

Contact: Jose Pardo, MD, PhD, 612-467-3164,

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Posted on 01/05/2015